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KMID : 0363819710050020041
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Korean Journal of Nuclear Medicine
1971 Volume.5 No. 2 p.41 ~ p.56
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Anemia of Chronic Liver Diseases
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申鉉正/Shin, Hyunchung
李正相/高昌舜/李文鎬/Lee, Jhung Sang/Koh, Chang Soon/Lee, Munho
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Abstract
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The pathogenetic mechanisms of anemia in patients with chronic liver disease were observed. Seventeen patients with moderate to advanced hepatic disease were studied by various methods. Only patients without previous blood loss were included: 14 had cirrhosis, 2 had active chronic hepatitis, and one had inferior vena cava obstruction with associated liver cirrhosis.
The followings were the results:
1. The anemia based on red blood cell count, Hb., and Ht. was found in 76. 5-78. 6% of the patients. 2. Red cell indices indicated that normo-macrocytic and normochromic anemia was present is the r-ajority of the patients.
.3. No evidence of megaloblastic anemia was found on the basis of the morphological examinations. -4. Serum iron, TIBC, % saturation and iron content in the bone marrow indicated that iron deficiency anemia was present in about half of the patients.
:5. In the view of the erythrocyte dynamics, primary increase in the red cell destruction was ascribed to the cause of the anemia.
-6. Decrease in the red cell survival time was not correlated with MCV, % saturation and S.L. ratio. Also, hemoglobin level was not correlated with MCV, % saturation and TsoCr. Therefore, multiple causes may be involved in the pathogenesis of the anemia.
7. Anemia as determined by the red cell volume was found in only 60% of the patients. It may be possible that hemodilutional anemia is present.
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